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Do not double doses Although many text books list a large number of side effects, the main ones are a low blood glucose level, stomach upsets, a metallic taste in the mouth, a skin rash and itching and weight gain which in some cases may be due to fluid retention.
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Therefore, SIRT1 induces glucose output from the liver in response to fasting via the deacetylation, and thereby inhibition, of STAT3 These results indicate that SIRT1 has a complex role in the regulation of hepatic glucose metabolism under different conditions through the alteration in the expression of gluconeogenesis genes and the modulation of CTRC2, PGC- , FOXO1, and STAT3 activity.
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